Dissolving microneedle for transdermal delivery of biopharmaceutical, and manufacturing method therefor
AssigneeDongguk University Industry-Academic Cooperation Foundation
InventorsHyo Kyung HAN, Jae Guen SONG
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Abstract
The present disclosure relates to a dissolving microneedle for transdermal delivery of biopharmaceuticals and a method of manufacturing the same. In the dissolving microneedle of the present disclosure, since biopharmaceuticals form a nanocomposite with aminoclay, the stability of the biopharmaceuticals and the mechanical strength of the microneedle are high, and the skin permeability of the biopharmaceutical is increased, thereby greatly improving transdermal delivery efficiency.
Claims14
A dissolving microneedle, comprising:
- a nanocomposite of a biopharmaceutical and aminoclay;
- and
- a hydrophilic polymer.
A method of manufacturing a dissolving microneedle, the method comprising:
- (i) mixing a biopharmaceutical and aminoclay to form a biopharmaceutical-aminoclay nanocomposite;
- (ii) mixing the biopharmaceutical-aminoclay nanocomposite with a hydrophilic polymer;
- (iii) injecting a mixture produced in step (ii) into a microneedle mold;
- and
- (iv) separating a microneedle from the microneedle mold after drying.
Dependencies are inferred from the claim text.