Heterocyclic-dithiol click chemistry

A method for transporting a molecule of interest across a cell membrane, comprising:

• (a) providing a functionalized molecule of interest comprising a moiety of Formula I:
• wherein
• W is independently selected from the group consisting of S and Se;
• Y is independently selected from the group consisting of S, Se, S(O), Se(O), S(O)2 and Se(O)2;
• and
• X together with W and Y forms a substituted or unsubstituted 3-10-membered heterocyclic ring;
• and
• (b) contacting a cell of interest with the functionalized molecule of interest under conditions for the moiety of Formula I to reversibly bind to one or more cell membrane transport proteins,
• thereby facilitating transport of the molecule of interest across the cell membrane.