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US 2025/0152482 A1Published application
Stabilized stannous compositions
AssigneeThe University of Melbourne
InventorEric Charles Reynolds
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AssigneeThe University of Melbourne
InventorEric Charles Reynolds
Estimating the term…
The present invention relates to improved complexes of amorphous calcium phosphate and/or calcium by amorphous fluoride phosphate stabilised phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.
A stannous-associated stabilized amorphous calcium phosphate (ACP) and/or amorphous calcium fluoride phosphate (ACFP) complex.
A method of producing a stannous-associated stabilized amorphous calcium phosphate (ACP) comprising the step of admixing CPP-ACP and a stannous compound in an aqueous solution, while maintaining the pH at about 6.5 or below.
A method of producing a stannous-associated stabilized amorphous calcium fluoride phosphate (ACFP) comprising the step of admixing CPP-ACFP and a stannous compound in an aqueous solution, while maintaining the pH at about 6.5 or below.
A composition including a stannous compound and stabilized ACP or ACFP.
A method of mineralizing a dental surface or sub-surface comprising contacting the dental surface or subsurface with a composition including a stannous compound and stabilized ACP or ACFP.
Dependencies are inferred from the claim text.