In vivo non-invasive measurement of blood parameters using laser enabled swept frequency acoustic interferometry

A system for measurement of blood parameters, the system comprising:

• a memory storing instructions;
• one or more Input/Output (I/O) interfaces;
• and
• one or more hardware processors coupled to the memory via the one or more I/O interfaces, wherein the one or more hardware processors are configured by the instructions to:
• acquire, via an ultrasound sensor, a Continuous Wave Laser diode based Photo Acoustic (CWPA) signal in frequency domain generated from laser excitation controlled by the one or more hardware processors and incident on a biological tissue of a subject carrying blood vessel based on a Laser Enabled Sweep Frequency Acoustic Interferometry (LE-SFAI) principle, wherein the LE-SFAI enabling a high Signal to Noise Ratio (SNR) CWPA signal;
• generate a time domain CWPA signal by applying an inverse Fourier transform on the CWPA signal and windowing the time-domain CWPA signal retaining a first peak followed by a second peak;
• analyze the time domain CWPA signal to determine a rise time of the first peak in the time domain CWPA signal, a peak amplitude of the first peak and a time difference between the first peak and the second peak;
• and
• determine a plurality of blood parameters of the subject, wherein the plurality of blood parameters comprise a blood viscosity, a Red Blood Corpuscles (RBC) concentration and a blood vessel diameter,
• wherein the blood viscosity is determined from the rise time of the time domain CWPA signal from the first peak in accordance with a blood viscosity calibration curve predetermined experimentally by observing relation between change in blood viscosity against change in the rise time of the time domain CWPA signal,
• wherein the RBC concentration is determined from the peak amplitude of the first peak in accordance with a RBC concentration calibration curve predetermined experimentally by observing relation between change RBC concentration against change in peak amplitude, and
• wherein the blood vessel diameter is determined using product of the time difference between the first peak and the second peak and the velocity of the time domain CWPA signal.

One or more non-transitory machine-readable information storage mediums comprising one or more instructions which when executed by one or more hardware processors cause:

• acquiring, via an ultrasound sensor, a Continuous Wave Laser diode based Photo Acoustic (CWPA) signal in frequency domain generated from laser excitation, controlled by one or more hardware processors, and incident on a biological tissue of a subject carrying blood vessel based on a Laser Enabled Sweep Frequency Acoustic Interferometry (LE-SFAI) principle controlled by one or more hardware processors, wherein the LE-SFAI enabling a high Signal to Noise Ratio (SNR) CWPA signal;
• generating, a time domain CWPA signal by applying an inverse Fourier transform on the CWPA signal and windowing the time-domain CWPA signal retaining a first peak followed by a second peak;
• analyzing, the time domain CWPA signal to determine a rise time of the first peak in the time domain CWPA signal, a peak amplitude of the first peak and a time difference between the first peak and the second peak;
• and
• determining, a plurality of blood parameters of the subject, wherein the plurality of blood parameters comprise a blood viscosity, a Red Blood Corpuscles (RBC) concentration and a blood vessel diameter,
• wherein the blood viscosity is determined from the rise time of the time domain CWPA signal from the first peak in accordance with a blood viscosity calibration curve predetermined experimentally by observing relation between change in blood viscosity against change in rise time of the time domain CWPA signal,
• wherein the RBC concentration is determined from the peak amplitude of the first peak in accordance with a RBC concentration calibration curve predetermined experimentally by observing relation between change RBC concentration against change in peak amplitude, and
• wherein the blood vessel diameter is determined using product of the time difference between the first peak and the second peak and the velocity of the time domain CWPA signal.