Methods and systems for federated querying of genomic and phenotypic data

A method for federated searching, comprising:

• providing a federated search system comprising a query hub in communication with a plurality of remote servers, each of the remote servers comprising phenotype and genotype information about a plurality of individuals;
• receiving, at a query hub of the federated search system, a query from a user, the query comprising a request for:
• (i) phenotype information, (ii) genotype information, and (iii) one or more attributes stored at the remote server for each individual satisfying both the request for phenotype information and the request for genotype information;
• iteratively distributing, by the query hub, the received query together with an incremental learning model to two or more of the plurality of remote servers;
• iteratively receiving, by the query hub, a response to the distributed query together with a trained version of the incremental learning model from each of the two or more of the plurality of remote servers;
• wherein said iteratively distributing and receiving comprises sending the received query together with an untrained incremental learning model to a first remote server and receiving together with the response a first trained version of the incremental learning model and sending the received query together with the first trained version of the incremental learning model to a second remote server and receiving a further response and a second trained version of the incremental learning model;
• aggregating, by the query hub, the received responses into a single aggregated response comprising both phenotype and genotype information;
• and
• providing, via a user interface of the federated search system, the single aggregated response and a latest trained version of the incremental learning model.