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AssigneesGenentech, Inc., Hoffmann-La Roche Inc.
InventorsSimon Paul KELOW, Daniel Joseph BERENBERG, Santrupti NERLI, Andrew Philip LEAVER-FAY, Jack Barton MAGUIRE, Michael Florian CHUNGYOUN, Andrew Martin WATKINS, Jae Hyeon LEE, Stephen Robert RA, Henri Vincent DWYER, Minji Maria LEE, Kyunghyun CHO, Richard A. BONNEAU, Vladimir GLIGORIJEVIC
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A method may include applying a protein sequence computation model to generate, based on an input protein sequence, a plurality of proposed protein sequences. A set of possible amino acid residues for each position in at least a portion of an output protein sequence may be identified based on the plurality of proposed protein sequences. A first protein structure having the output protein sequence may be generated by applying a protein structure computation model to select, for each position in at least the portion of the output protein sequence, an amino acid residue from a corresponding set of possible amino acid residues. The protein structure computation model may further determine the conformation of the amino acid residues selected for inclusion in the output protein sequence. In some cases, the first protein structure may be grafted onto a second protein structure to form a third protein structure.
A system, comprising:
A computer-implemented method, comprising:
A non-transitory computer readable medium storing instructions, which when executed by at least one data processor, result in operations comprising;
Dependencies are inferred from the claim text.