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US 2025/0147030 A1Published application
Peptide-encoded libraries of small molecules for de novo drug discovery
AssigneeMassachusetts Institute of Technology
InventorsStephen L. Buchwald, Bradley L. Pentelute, Nathalie Grob, Simon Roessler
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Abstract
Disclosed are conjugates and methods of identifying ligands for substrates using said conjugates. Also disclosed herein are methods of making the conjugates.
Claims26
A conjugate having a structure represented by formula I or a salt thereof:
- wherein
- A is a resin;
- B is a branching unit;
- D is hydrogen, a carboxy protecting group, an amino protecting group, or an encoding peptide tag;
- E is a cleavable moiety;
- X is hydrogen, halo, amino, carboxy, protected, amino, protected carboxy, a small molecule, alkyl, alkene, alkyne, aryl, ketone, acyl, aldehyde, hydroxy, or a plurality of small molecules;
- L1 is a cleavable covalent linker;
- L2 is a covalent linker;
- and
- L3 is a covalent linker.
7 more elements
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-128. (canceled)
Dependencies are inferred from the claim text.