US 2025/0147003 A1 · Determination Of The Cell Concentration And/Or Platelet Mass Index Of A Fluid

Abstract

An optical detection assembly for monitoring a fluid includes a light source, a light detector array, and a controller. The controller receives signals from the light detector array that are indicative of the intensity of light received by the light detector array after the light has passed through the fluid. The controller generates a scattering profile based on the signals, with the scattering profile including rising and falling edges each having a slope. The controller calculates one or both slopes and determines the platelet mass index (for a platelet-containing fluid) and/or the concentration of a substance in the fluid based on said slope(s). The optical detection assembly may also be used to analyze a reference fluid having a known concentration of the substance, with signals received by the controller when analyzing the reference fluid being a factor when determining the concentration of the substance in the fluid of interest.

Claims21

Dependent claims

An optical detection assembly for monitoring a fluid in a vessel, comprising:

a light source configured and oriented to emit a light into a fluid in a vessel;
a light detector array comprising a plurality of light detectors and configured to receive at least a portion of the light exiting the vessel;
and
a controller programmed to
receive signals from the light detector array indicative of an intensity of said at least a portion of the light received by each one of said plurality of light detectors,
generate a scattering profile based at least in part on said signals from the light detector array, with the scattering profile including a rising edge and a falling edge,
calculate a slope of the rising edge or the falling edge of the scattering profile, and
determine a platelet mass index and/or a concentration of a substance in the fluid in the vessel based at least in part on said slope.

5 more elements

A biological fluid processing device comprising:

a pump system;
a valve system;
a controller programmed to control the operation of the pump system and the valve system to execute a biological fluid processing procedure;
and
an optical detection assembly comprising
a light source configured and oriented to emit a light into a fluid in a vessel, and
a light detector array comprising a plurality of light detectors and configured to receive at least a portion of the light exiting the vessel, wherein the controller is further programmed to
receive signals from the light detector array indicative of an intensity of said at least a portion of the light received by each one of said plurality of light detectors,
generate a scattering profile based at least in part on said signals from the light detector array, with the scattering profile including a rising edge and a falling edge,
calculate a slope of the rising edge or the falling edge of the scattering profile, and
determine a platelet mass index and/or a concentration of a substance in the fluid in the vessel based at least in part on said slope.

8 more elements

Dependencies are inferred from the claim text.

Determination Of The Cell Concentration And/Or Platelet Mass Index Of A Fluid

Life of this patent

Determination Of The Cell Concentration And/Or Platelet Mass Index Of A Fluid

Life of this patent

Abstract

Claims21