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US 2025/0146050 A1Published application
Stabilisation of biological samples
AssigneePreanalytix GmbH
InventorsMartin Horlitz, Annabelle Schubert, Markus Sprenger-Haussels, Kalle Günther, Ralf Wyrich, Uwe Oelmüller
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Abstract
The present invention provides methods, compositions and devices for stabilizing the extracellular nucleic acid population in a cell-containing biological sample and for stabilizing the transcriptome of contained cells.
Claims20
A container for collecting a cell-containing biological sample, wherein the container comprises a composition capable of stabilizing a cell-containing biological sample, the composition comprising:
- a) at least one N,N-dialkylpropanamide according to formula 1
- wherein R1 is a hydrogen residue or an alkyl residue, R2 and R3 are identical or different hydrocarbon residues with a length of the carbon chain of 1-20 atoms arranged in a linear or branched manner, and R4 is an oxygen, sulphur or selenium residue;
- and
- b) at least one anticoagulant,
- wherein the container is evacuated to an internal pressure that is selected to draw a predetermined volume of a cell-containing biological sample.
2 more elements
Dependencies are inferred from the claim text.