US 2025/0146035 A1Published application

Biocatalyst and methods for synthesizing mixed disulfide conjugates of thienopyridine compounds

AssigneeThe Regents of the University of Michigan

InventorHaoming ZHANG

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Abstract

The present invention relates to methods for synthesizing mixed disulfide conjugates of thienopyridine compounds with a genetically engineered variant of cytochrome P450 BM3 or CYP102A1 as a catalyst, and belongs to the field of chemical synthesis.

Claims31

Dependent claims

A mutant CYP102A1 enzyme capable of catalyzing conjugation between 2-oxo thienopyridine and heterocyclic thiols in the presence of a reducing reagent.

Dependencies are inferred from the claim text.

Facts

Application: 19/012,148Filed 7 Jan 2025
Priority: 31 Jan 2018
Published: 8 May 2025
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

C12N 9/0071
Oxidoreductases: acting on paired donors with incorporation of molecular oxygen
C12P 17/167
Containing two or more hetero rings: heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
A61K 31/4535
Containing further heterocyclic ring systems: containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…

Family

Application62/624,494Us provisional application · filed 31 Jan 2018
Application16/966,359Continuation · filed 30 Jul 2020
Application19/012,148Continuation
US 12,188,069 B2Related patent
US 2020/0370081 A1Published application
US 2025/0146035 A1This patent

From the US filing history. Foreign family members aren’t listed.

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