Back to results
US 2025/0146019 A1Published application
Cd8 polypeptides, compositions, and methods of using thereof
AssigneeImmatics US, Inc.
InventorsGagan BAJWA, Mamta KALRA, Melinda MATA
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to T cells capable of co-expressing T cell receptors (“TCR”) together with CD8 polypeptides and the use thereof in adoptive cellular therapy. The present disclosure further provides for modified CD8 sequences, vectors, and associated methods thereof.
Claims28
A nucleic acid comprising a nucleic acid sequence encoding:
- (i) a T-cell receptor (TCR) comprising a TCR α chain and a TCR β chain;
- and
- (ii) a CD8 polypeptide comprising an amino acid sequence which is at least 95% identical to SEQ ID NO:
- 5, 258, 259, 262, or a variant thereof.
1 more element
A polypeptide comprising an amino acid sequence which is at least 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence of SEQ ID NO:
- 5, 258, 259, 262, or a variant thereof.
Dependencies are inferred from the claim text.