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OwnerMarc GÜELL CARGOL, Nastassia KNÖDLSEDER +3inventors
InventorsMarc GÜELL CARGOL, Nastassia KNÖDLSEDER, María José FÁBREGA FERNÁNDEZ, Javier SANTOS MORENO, Guillermo NEVOT SÁNCHEZ
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The present invention relates to recombinant C. acnes and method of producing thereof. The present invention provides a human neutrophil gelatinase-associated lipocalin (NGAL) protein derived from a recombinant bacterium and its uses thereof. Particularly, the present invention relates to the use of NGAL protein obtained from a recombinant bacterium in the treatment of acne vulgaris or as a cosmetical composition. Provided herein are also recombinant bacterium expressing NGAL protein and their uses.
A method for introducing a nucleic acid into Cutibacterium acnes (C. acnes), the method comprising the steps of:
The method according to any one of the previous claims, wherein the nucleic acid comprises C. acnes integration elements that lead the integration of said target nucleic acid or at least a portion thereof in the genome of C. acnes.
The method according to any of the previous claims, wherein the C. acnes that have been transformed are selected, and wherein the selection is based on at least two bacterial selection markers.
A recombinant Cutibacterium acnes characterized in that it expresses the human neutrophil gelatinase-associated lipocalin (NGAL) protein.
Dependencies are inferred from the claim text.