Compositions and methods for producing smooth muscle cells
AssigneesThe Regents of the University of California, GlaxoSmithKline Intellectual Property Development Limited
InventorsRustam Esanov, Yeqing Angela Yang, Volkan Sevim, Kaivalya Shevade, Laralynne Przybyla, Shawn Shafer
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Abstract
Methods and compositions are provided for producing a smooth muscle cell (SMC) from a pluripotent stem cell, e.g., an induced pluripotent stem cell (iPSC), via MEOX1 overexpression. MEOX1 expression can be induced using any convenient method, e.g., by introducing an exogenous nucleic acid encoding MEOX1 or by using a tool such as CRISPRa to stimulate expression from the MEOX1 endogenous locus.
Claims20
A method producing a smooth muscle cell (SMC), the method comprising:
- overexpressing MEOX1 expression in a pluripotent stem cell (PSC), thereby producing an SMC.
Dependencies are inferred from the claim text.