Bioreactor

Abstract

There is provided a method of culturing cells comprising: providing a bioreactor, wherein the bioreactor contains a particulate substrate arranged as a fixed bed; seeding the particulate substrate with myoblasts, myocytes, and/or myotubes; culturing the cells by flowing cell culture medium through the fixed bed such that the fixed bed conditions are maintained. Also provided is a flow distributor for a bioreactor comprising: a first surface and a second surface, wherein the first surface is on the opposite side of the flow distributor to the second surface, and wherein the flow distributor has a central axis extending through the flow distributor; and a plurality of channels within the flow distributor, wherein the plurality of channels each have an inlet and an outlet.

Dependencies are inferred from the claim text.