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US 2025/0145828 A1Published application
Transparent protein materials
AssigneeTandem Repeat Technologies, Inc.
InventorsBenjamin D. ALLEN, Huihun JUNG
Life of this patent
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Abstract
As can be seen, there are needs for protein materials that have desirable mechanical properties while maintaining optical transparency. The present embodiments are directed, in part, to adhesive coatings, films, and compositions comprising polypeptides such as, but not limited to, transparent adhesive coatings and films, and methods of making the same.
Claims15
A polypeptide having a formula:
- A1-(B1-L1-E1-P1)n-B1-G1 Formula I,
- wherein
- A1 is absent, is a methionine, or is an amino acid sequence 1 to 4 residues in length;
- B1 is an ASTVH-rich sequence amino acid sequence 6 to 17 residues in length comprising amino acids selected from the group consisting of alanine, serine, threonine, valine, histidine, glycine, glutamine, and proline, or any combination thereof.
- L1 is absent or is an amino acid sequence 1 to 7 residues in length comprising amino acids selected from the group consisting of proline, glycine, leucine, serine, and threonine, or any combination thereof;
- E1 is an GLY-rich amino acid sequence 8 to 58 residues in length comprising amino acids selected from the group consisting of glycine, leucine, tyrosine, phenylalanine, and proline, or any combination thereof;
- P1 is absent or is proline;
- G1 is absent or is an amino acid sequence 1 to 4 residues in length;
- wherein n is 4 to 100;
- and
- (i) wherein E1 is YGFGGLYGGLFGGLGFG (SEQ ID NO:3) and B1 comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
- 11-88, or
- (ii) wherein E1 is YGYGGLFGGLFGGLGYG (SEQ ID NO:2) and B1 comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
- 12, 13, 17, 19-39, 41-52, 54-59, 61, 64-68, 70-78, 80, 82-84, and 88, or
- (iii) wherein E1 is YGYGGLYGGLYGGLGYG (SEQ ID NO:1) and B1 comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
- 12, 24, 27, 35, 37, 39, 55, 66, 67, 68, 71, 76, 82, and 83, or
- (iv) wherein E1 comprises an amino acid sequence selected from the group consisting of SEQ ID NO:90-204, B1 comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
- 13, 21-23, 25, 26, 29, 30, 32, 34, 36, 37, 39, 44-46, 48, 50-52, 55, 57, 58, 61, 64-68, 71, 72, 74, 76-78, 80-83, and 89, and L1 is absent or is Pro.
15 more elements
Dependencies are inferred from the claim text.