Anti-pd-l1/anti-4-1bb bispecific antibodies and uses thereof

A polynucleotide encoding an anti-PD-L1/anti-4-1BB bispecific antibody, comprising an anti-PD-L1 antibody or an antigen-binding fragment thereof and an anti-4-1BB antibody or an antigen-binding fragment thereof, wherein

• the anti-PD-L1 antibody or antigen-binding fragment thereof comprises a VH CDR1 comprising the amino acid sequence of SEQ ID NO:
• 1;
• a VH CDR2 comprising the amino acid sequence selected from the group consisting of SEQ ID NOS:
• 2 and 3;
• a VH CDR3 comprising the amino acid sequence selected from the group consisting of SEQ ID NOS:
• 4, 5, 262, 263, 264, 265, 266 and 267;
• a VL CDR1 comprising the amino acid sequence selected from the group consisting of SEQ ID NOS:
• 6, 268 and 269;
• a VL CDR2 comprising the amino acid sequence of SEQ ID NO:
• 7;
• and a VL CDR3 comprising the amino acid sequence selected from the group consisting of SEQ ID NOS:
• 8, 270, 271 and 272;
• and
• the anti-4-1BB antibody or antigen-binding fragment thereof comprises a VH CDR1 comprising the amino acid sequence selected from the group consisting of SEQ ID NOS:
• 10 and 11;
• a VH CDR2 comprising the amino acid sequence selected from the group consisting of SEQ ID NOS:
• 12 and 13;
• a VH CDR3 comprising the amino acid sequence selected from the group consisting of SEQ ID NOS:
• 14, 15, 16 and 17;
• a VL CDR1 comprising the amino acid sequence of SEQ ID NO:
• 18;
• a VL CDR2 comprising the amino acid sequence of SEQ ID NO:
• 19;
• and a VL CDR3 comprising the amino acid sequence of SEQ ID NO:
• 20.