Anti-siglec-7 antibodies and methods of use thereof
AssigneeAlector LLC
InventorsPatricia CULP, Seung-Joo LEE, Helen LAM, Wei-Hsien HO, Arnon ROSENTHAL
Life of this patent
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Abstract
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
Claims50
An antibody that binds to a Siglec-7 protein, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises:
- an HVR-H1 comprising a sequence according to Formula I:
- GYAFTX1X2WMN (SEQ ID NO:
- 6), wherein X1 is E, M, G, or A, and X2 is T, A, or Y;
- an HVR-H2 comprising a sequence according to Formula II:
- RIFPGX1GHTN (SEQ ID NO:
- 9), wherein X1 is L or Y;
- and
- an HVR-H3 comprising the sequence of DYSDYYFDY (SEQ ID NO:
- 10);
- and
- the light chain variable region comprises:
- an HVR-L1 comprising a sequence according to Formula III:
- RX1SX2DX NTYLN (SEQ ID NO:
- 15), wherein X1 is G or A, X2 is Q or E, and X3 is I, T, or A;
- an HVR-L2 comprising the sequence of YTSRLHS (SEQ ID NO:
- 16);
- and
- an HVR-L3 comprising a sequence according to Formula IV:
- QX1GX2X3X4PWT (SEQ ID NO:
- 24), wherein X1 is Q or G, X2 is N or G, X3 is L, T, V, or I, and X4 is L or K.
An antibody that binds to a Siglec-7 protein, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises:
- an HVR-H1 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-5;
- an HVR-H2 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 7-8;
- and
- an HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 10;
- and
- the light chain variable region comprises:
- an HVR-L1 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 11-14;
- an HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 16;
- and
- an HVR-L3 comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 17-23.
An antibody that binds to a Siglec-7 protein, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein:
- the heavy chain variable region comprises an HVR-H1 comprising the amino acid sequence GYAFTMAWMN (SEQ ID NO:
- 2), an HVR-H2 comprising the amino acid sequence RIFPGYGHTN (SEQ ID NO:
- 8), and an HVR-H3 comprising the amino acid sequence DYSDYYFDY (SEQ ID NO:
- 10), and the light chain variable region comprises an HVR-L1 comprising the amino acid sequence RGSQDINTYLN (SEQ ID NO:
- 11), an HVR-L2 comprising the amino acid sequence YTSRLHS (SEQ ID NO:
- 16), and an HVR-L3 comprising the amino acid sequence QQGNLLPWT (SEQ ID NO:
- 17).
An antibody that binds to a Siglec-7 protein, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein:
- the heavy chain variable region comprises an HVR-H1 comprising the amino acid sequence GYAFTGYWMN (SEQ ID NO:
- 3), an HVR-H2 comprising the amino acid sequence RIFPGLGHTN (SEQ ID NO:
- 7), and an HVR-H3 comprising the amino acid sequence DYSDYYFDY (SEQ ID NO:
- 10), and the light chain variable region comprises an HVR-L1 comprising the amino acid sequence RGSQDTNTYLN (SEQ ID NO:
- 12), an HVR-L2 comprising the amino acid sequence YTSRLHS (SEQ ID NO:
- 16), and an HVR-L3 comprising the amino acid sequence QQGNTLPWT (SEQ ID NO:
- 20).
An antibody that binds to a Siglec-7 protein, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein:
- the heavy chain variable region comprises an HVR-H1 comprising the amino acid sequence GYAFTGYWMN (SEQ ID NO:
- 3), an HVR-H2 comprising the amino acid sequence RIFPGLGHTN (SEQ ID NO:
- 7), and an HVR-H3 comprising the amino acid sequence DYSDYYFDY (SEQ ID NO:
- 10), and the light chain variable region comprises an HVR-L1 comprising the amino acid sequence RGSQDINTYLN (SEQ ID NO:
- 11), an HVR-L2 comprising the amino acid sequence YTSRLHS (SEQ ID NO:
- 16), and an HVR-L3 comprising the amino acid sequence QQGNILPWT (SEQ ID NO:
- 23).
An antibody that binds to a Siglec-7 protein, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein:
- the heavy chain variable region comprises an HVR-H1 comprising the amino acid sequence GYAFTAAWMN (SEQ ID NO:
- 4), an HVR-H2 comprising the amino acid sequence RIFPGLGHTN (SEQ ID NO:
- 7), and an HVR-H3 comprising the amino acid sequence DYSDYYFDY (SEQ ID NO:
- 10), and the light chain variable region comprises an HVR-L1 comprising the amino acid sequence RGSQDINTYLN (SEQ ID NO:
- 11), an HVR-L2 comprising the amino acid sequence YTSRLHS (SEQ ID NO:
- 16), and an HVR-L3 comprising the amino acid sequence QQGNILPWT (SEQ ID NO:
- 23).
An antibody that binds to a Siglec-7 protein, wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 41 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 52.
An antibody that binds to a Siglec-7 protein, wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 42 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 55.
An antibody that binds to a Siglec-7 protein, wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 42 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 60.
An antibody that binds to a Siglec-7 protein, wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 43 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 60.
Dependencies are inferred from the claim text.