Gprc5d antibody and application thereof

An antibody or an antigen-binding fragment thereof that specifically binds to G protein coupled receptor C5 family subtype D (GPRC5D), wherein the antibody or the antigen-binding fragment thereof comprises a heavy chain variable region and a light chain variable region, and wherein

• (1) the light chain variable region comprises LCDR1, LCDR2 and LCDR3, the LCDR1 has any of a sequence of the following LCDR1, or a sequence with 1, 2, 3 or more amino acid insertions, deletions and/or substitutions compared with the sequence, the LCDR2 has any of a sequence of the following LCDR2, or a sequence with 1, 2, 3 or more amino acid insertions, deletions and/or substitutions compared with the sequence, and the LCDR3 has any of a sequence of the following LCDR3, or a sequence with 1, 2, 3 or more amino acid insertions, deletions and/or substitutions compared with the sequence:
• No.
• LCDR1
• LCDR2
• LCDR3
• L1
• SEQ ID NO:
• 35
• SEQ ID NO:
• 36
• SEQ ID NO:
• 37
• L2
• SEQ ID NO:
• 38
• SEQ ID NO:
• 39
• SEQ ID NO:
• 37
• L3
• SEQ ID NO:
• 46
• SEQ ID NO:
• 47
• SEQ ID NO:
• 48
• L4
• SEQ ID NO:
• 49
• SEQ ID NO:
• 50
• SEQ ID NO:
• 48
• L5
• SEQ ID NO:
• 57
• SEQ ID NO:
• 58
• SEQ ID NO:
• 59
• L6
• SEQ ID NO:
• 60
• SEQ ID NO:
• 61
• SEQ ID NO:
• 59
• L7
• SEQ ID NO:
• 68
• SEQ ID NO:
• 69
• SEQ ID NO:
• 70
• L8
• SEQ ID NO:
• 71
• SEQ ID NO:
• 72
• SEQ ID NO:
• 70
• L9
• SEQ ID NO:
• 79
• SEQ ID NO:
• 80
• SEQ ID NO:
• 81
• L10
• SEQ ID NO:
• 82
• SEQ ID NO:
• 83
• SEQ ID NO:
• 81
• L11
• SEQ ID NO:
• 90
• SEQ ID NO:
• 91
• SEQ ID NO:
• 92
• L12
• SEQ ID NO:
• 93
• SEQ ID NO:
• 94
• SEQ ID NO:
• 92
• L13
• SEQ ID NO:
• 101
• SEQ ID NO:
• 102
• SEQ ID NO:
• 103
• L14
• SEQ ID NO:
• 104
• SEQ ID NO:
• 105
• SEQ ID NO:
• 103
• L15
• SEQ ID NO:
• 112
• SEQ ID NO:
• 113
• SEQ ID NO:
• 114
• L16
• SEQ ID NO:
• 115
• SEQ ID NO:
• 116
• SEQ ID NO:
• 114
• L17
• SEQ ID NO:
• 217
• SEQ ID NO:
• 102
• SEQ ID NO:
• 103
• L18
• SEQ ID NO:
• 227
• SEQ ID NO:
• 102
• SEQ ID NO:
• 103
• L19
• SEQ ID NO:
• 228
• SEQ ID NO:
• 102
• SEQ ID NO:
• 103
• L20
• SEQ ID NO:
• 229
• SEQ ID NO:
• 102
• SEQ ID NO:
• 103
• L21
• SEQ ID NO:
• 230
• SEQ ID NO:
• 102
• SEQ ID NO:
• 103
• and,
• (2) the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3, the HCDR1 has any of a sequence of the following HCDR1, or a sequence with 1, 2, 3 or more amino acid insertions, deletions and/or substitutions compared with the sequence, the HCDR2 has any of a sequence of the following HCDR2, or a sequence with 1, 2, 3 or more amino acid insertions, deletions and/or substitutions compared with the sequence, and the HCDR3 has any of a sequence of the following HCDR3, or a sequence with 1, 2, 3 or more amino acid insertions, deletions and/or substitutions compared with the sequence:
• No.
• HCDR1
• HCDR2
• HCDR3
• H1
• SEQ ID NO:
• 29
• SEQ ID NO:
• 30
• SEQ ID NO:
• 31
• H2
• SEQ ID NO:
• 32
• SEQ ID NO:
• 33
• SEQ ID NO:
• 34
• H3
• SEQ ID NO:
• 40
• SEQ ID NO:
• 41
• SEQ ID NO:
• 42
• H4
• SEQ ID NO:
• 43
• SEQ ID NO:
• 44
• SEQ ID NO:
• 45
• H5
• SEQ ID NO:
• 51
• SEQ ID NO:
• 52
• SEQ ID NO:
• 53
• H6
• SEQ ID NO:
• 54
• SEQ ID NO:
• 55
• SEQ ID NO:
• 56
• H7
• SEQ ID NO:
• 62
• SEQ ID NO:
• 63
• SEQ ID NO:
• 64
• H8
• SEQ ID NO:
• 65
• SEQ ID NO:
• 66
• SEQ ID NO:
• 67
• H9
• SEQ ID NO:
• 73
• SEQ ID NO:
• 74
• SEQ ID NO:
• 75
• H10
• SEQ ID NO:
• 76
• SEQ ID NO:
• 77
• SEQ ID NO:
• 78
• H11
• SEQ ID NO:
• 84
• SEQ ID NO:
• 85
• SEQ ID NO:
• 86
• H12
• SEQ ID NO:
• 87
• SEQ ID NO:
• 88
• SEQ ID NO:
• 89
• H13
• SEQ ID NO:
• 95
• SEQ ID NO:
• 96
• SEQ ID NO:
• 97
• H14
• SEQ ID NO:
• 98
• SEQ ID NO:
• 99
• SEQ ID NO:
• 100
• H15
• SEQ ID NO:
• 106
• SEQ ID NO:
• 107
• SEQ ID NO:
• 108
• H16
• SEQ ID NO:
• 109
• SEQ ID NO:
• 110
• SEQ ID NO:
• 111
• H17
• SEQ ID NO:
• 40
• SEQ ID NO:
• 142
• SEQ ID NO:
• 42
• H18
• SEQ ID NO:
• 40
• SEQ ID NO:
• 143
• SEQ ID NO:
• 42
• H19
• SEQ ID NO:
• 51
• SEQ ID NO:
• 158
• SEQ ID NO:
• 53
• H20
• SEQ ID NO:
• 51
• SEQ ID NO:
• 159
• SEQ ID NO:
• 53
• preferably, the antibody or the antigen-binding fragment thereof comprises sequences of six CDRs in the following combination of a light chain variable region and a heavy chain variable region:
• L1+H1, L2+H2, L3+H3, L4+H4, L5+H5, L6+H6, L7+H7, L8+H8, L9+H9, L10+H10, L11+H11, L12+H12, L13+H13, L14+H14, L15+H15, L16+H16, L3+H17, L3+H18, L5+H19, L5+H20, L17+H13, L18+H13, L19+H13, L20+H13 or L21+H13, or sequences of six CDRs having 1, 2, 3 or more amino acid insertions, deletions and/or substitutions compared with the sequences of six CDRs.