Single-chain trail-receptor agonist proteins
AssigneesAbbVie Inc., Apogenix AG
InventorsFritz G. Buchanan, Christian Gieffers, Oliver Hill, Susan E. Lappe, Darren C. Phillips, Meinolf Thiemann
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Abstract
Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
Claims9
A TRAIL receptor agonist protein comprising a polypeptide having the amino acid sequence set forth in SEQ ID NO:
- 19.
A TRAIL receptor agonist protein comprising two polypeptides having the amino acid sequence set forth in SEQ ID NO:
- 19.
-22. (canceled)
Dependencies are inferred from the claim text.