Heterodimeric polypeptide complexes comprising il-15 variants and uses thereof

The polypeptide complex of claim 51, comprising a first chain and a second chain, wherein:

• (a) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 19, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 20;
• (b) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 70, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 71;
• (c) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 72, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 73;
• (d) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 74, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 75;
• (e) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 21, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 22;
• (f) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 23, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 24;
• (g) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 25, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 26;
• (h) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 76, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 77;
• (i) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 13, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 14;
• (j) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 15, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 16;
• (k) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 17, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 18;
• (l) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 39, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 40;
• (m) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 41, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 42;
• (n) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 43, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 44;
• (o) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 45, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 46;
• (p) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 47, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 48;
• or
• (q) the first chain comprises an amino acid sequence as set forth in SEQ ID No:
• 49, and the second chain comprises an amino acid sequence as set forth in SEQ ID No:
• 50.

A polypeptide complex comprising an Interleukin-15 (IL-15) variant domain, an IL-15Rα domain, a first dimerization domain and a second dimerization domain, wherein:

• the IL-15 variant domain comprises an IL-15 variant peptide of the amino acid sequence of any of SEQ ID Nos:
• 51-69;
• and
• the first dimerization domain and the second dimerization domain associates together to form a dimer.