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US 2025/0145677 A1Published application
Engineered semaphorins and uses thereof
AssigneeChildren's Medical Center Corporation
InventorsDavid M. BRISCOE, Diane BIELENBERG, Johannes WEDEL
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Abstract
Provided herein are methods and compositions comprising or using mutant semaphorin polypeptides.
Claims20
A semaphorin (SEMA) polypeptide, wherein the proproteinase cleavage motif is inactivated by mutation, and wherein the proproteinase cleavage motif is selected from the group consisting of:
- RXXR, RXKR, RXRR, SEQ ID NO:
- 15, and SEQ ID NO:
- 16.
A multispecific agent comprising a semaphorin polypeptide that binds to neuropilin 2, and an agent that binds an immunomodulator polypeptide.
Dependencies are inferred from the claim text.