US 2025/0145665 A1Published application

Macrocyclic peptides useful as modulators of tnf alpha

OwnerYong Zhang, Alaric J. Dyckman +10inventors

InventorsYong Zhang, Alaric J. Dyckman, Ving G. Lee, Zheming Ruan, Jason Goodrich, Lidet A. Negash, Saleem Ahmad, Hong Wu, John Hynes, Michael A. Poss, Alexander C. Brueckner, Sirish Kaushik Lakkaraju

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Abstract

Disclosed are macrocyclic peptide compounds or a salt thereof, which are useful as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds may be useful in treating cancers, inflammatory and autoimmune diseases.

Claims4

Dependent claims

A compound selected from any of the exemplified compounds.

Dependencies are inferred from the claim text.

Facts

Application: 18/789,771Filed 31 Jul 2024
Priority: 2 Aug 2023
Published: 8 May 2025
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07K 7/56
With at least one abnormal peptide link in the ring: the cyclisation not occurring through 2,4-diamino-butanoic acid
A61P 37/06
Immunomodulators: immunosuppressants, e.g. drugs for graft rejection
A61K 38/00
Medicinal preparations containing peptides
C07K
Peptides

Family

Application63/517,153Us provisional application · filed 2 Aug 2023
US 2025/0145665 A1This patent

From the US filing history. Foreign family members aren’t listed.

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