Synthesis of cholesterol form bisnoralcohol
AssigneeFermenta Biotech Limited
InventorsAnupama DATLA, Prashant NAGRE, Jagdish TAMORE, Sachin Govind WADHAVANE, Amol SHIRSATH, Gajanan Subhash GAONKAR
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Abstract
The present invention discloses a short, cost effective process for preparation of cholesterol from bisnoralcohol (BA).
Claims9
A short, cost effective process for the preparation of cholesterol from bisnoralcohol comprising;
- i. Tosylating Bisnoralcohol to obtain bisnoralcohol tosylate (2);
- ii. Converting the compound (2) to 3-Ketal BisnoralcoholTosylate (3) with ethylene glycol in presence of alkyl ester of orthoformic acid;
- iii. Treating the compound (3) with Grignard reagent to obtain 3-Ketal Cholestenone (4);
- iv. Deprotecting compound (4) to give Cholest-4-ene-3-none (5) in presence of acid and water;
- V. Acetylating compound (5) to give 3-Acetoxy-Cholest-3,5-diene (6);
- and
- vi. Reducing the compound (6) to obtain cholesterol by in-situ generation of calcium borohydride.
The process as claimed in any one of the preceding claims wherein the solvent for the process is selected from lower alcohols, halogenated hydrocarbons, aliphatic or aromatic hydrocarbons, ethers, diazoles, esters, ketones, nitriles and the like alone or mixtures thereof.
The process as claimed in any one of the preceding claims wherein the base is selected from organic or inorganic bases.
Dependencies are inferred from the claim text.