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OwnerBrett Bookser, Iriny Botrous +9inventors
InventorsBrett Bookser, Iriny Botrous, Aaron Burns, DeMichael Chung, Brian Dyck, Andrew Kleinke, Dange Vijay Kumar, Margaret McCarrick, Nicholas Raffaele, Joe Tran, Michael Weinhouse
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Substituted furanopyrimidine chemical entities of Formula (I): wherein Ra has any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by PDE1 activity or dopaminergic signaling; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including cardiovascular, renal, hematological, gastroenterological, liver, cancer, fertility, and metabolic disorders.
-134. (canceled)
A method of enhancing memory in a subject with a cognitive disorder, comprising administering to the subject an effective amount of a compound, or pharmaceutically acceptable salt thereof, selected from the group consisting of:
A method of treating a dyskinetic disorder associated with Parkinson's disease, comprising administering to a subject in need thereof an effective amount of a compound, or pharmaceutically acceptable salt thereof, selected from the group consisting of:
Dependencies are inferred from the claim text.