3-substituted pyridazine compounds as smarca2 and/or smarca4 degraders

A compound of formula (I):

• or a pharmaceutically acceptable salt or a stereoisomer or a tautomer thereof;
• wherein,
• A represents 5- to 6-membered heteroarylenyl or 6-membered arylenyl;
• wherein the arylenyl and heteroarylenyl are unsubstituted or substituted with 1, 2 or 3 Ra;
• Ra, at each occurrence, independently represents hydroxy, hydroxyalkyl, halogen, alkoxy, alkyl, haloalkyl or cyano;
• R1 is halogen, alkyl, haloalkyl, alkoxy, hydroxy, hydroxyalkyl, 6- to 10-membered aryl or 5- to 10-membered heteroaryl;
• wherein the aryl and heteroaryl groups are unsubstituted or substituted with 1, 2 or 3 substituent(s) independently selected from oxo, hydroxy, alkoxy, halogen, alkyl, haloalkyl, amino and cyano;
• R2 is hydrogen, hydroxy, hydroxyalkyl, halogen, alkoxy, alkyl, amino, aminoalkyl, haloalkyl or cyano;
• Q is amino, aminoalkyl, hydroxy, hydroxyalkyl, halogen, alkoxy, alkyl, haloalkyl or cyano;
• L is a bond, —N(Rx)—(CRxRy)p-O—, —O—(CRxRy)p-, —O—(CRxRy)p-O—, —C≡C—(CRxRy)p-, -heterocycloalkylenyl-heterocycloalkylenyl-, -heterocycloalkylenyl-O—, -heterocycloalkylenyl-C≡C—, —C≡C-heterocycloalkylenyl-, —O-heterocycloalkylenyl-(CRxRy)p-, —N(Rx)-heterocycloalkylenyl-(CRxRy)p-, -cycloalkylenyl-(CRxRy)p-, -heteroarylenyl-(CRxRy)p-, -heterocycloalkylenyl-(CRxRy)p-, -heterocycloalkylenyl-(CRxRy)p1-heterocycloalkylenyl- or -heterocycloalkylenyl-O-heterocycloalkylenyl-;
• wherein the cycloalkylenyl, heteroarylenyl and heterocycloalkylenyl are unsubstituted or substituted with 1, 2 or 3 Rd;
• and the left side of L group is attached to A and right side of L group is attached to M;
• Rd, at each occurrence, is independently selected from hydroxy, halogen, alkyl and alkoxy;
• or any two Rd groups attached with the same C atom together form an oxo group;
• Rx and Ry, at each occurrence, are independently selected from hydrogen and alkyl;
• M is selected from M-1 and M-2:
• wherein
• Z is 5- to 6-membered heteroarylenyl or 5- to 6-membered heterocycloalkylenyl;
• wherein the heteroarylenyl and heterocycloalkylenyl groups are unsubstituted or substituted with oxo, hydroxy, halogen, alkyl or alkoxy;
• R3 and R8 independently represents alkyl, haloalkyl or hydroxyalkyl;
• R4 and R9 independently represents hydrogen, alkyl, haloalkyl or hydroxyalkyl;
• R5, R6, R10 and R11 are independently selected from hydrogen, alkyl, halogen, heteroalkyl, haloalkyl, hydroxyalkyl and acyl;
• R7 and R12 independently represents thiazolyl which is unsubstituted or substituted with alkyl, hydroxy, amino or haloalkyl;
• ‘p’ is an integer selected from 0, 1, 2, 3, 4, 5 and 6;
• and
• ‘p1’ is an integer selected from 1, 2, 3 and 4.