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US 2025/0145593 A1Published application
Dantrolene prodrugs and methods of their use
AssigneeEagle Research Labs Limited
InventorsCharles WESCOTT, Adrian HEPNER, Alyssa LARSON
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Abstract
The disclosure is directed to dantrolene prodrugs, compositions thereof, and methods of their use in the treatment of disease.
Claims30
A pharmaceutical composition comprising the compound of formula I
- wherein
- R is —P(O)(OR1)(OR2);
- R1 is H, —C1-26alkyl, aryl, —C1-6alkC(O)O—C1-26alkyl, —C1alkOC(O)C1-26alkyl, or —C1alkOC(O)OC1-26alkyl;
- and
- R2 is —C1-26alkyl, aryl, —C1-6alkC(O)O—C1-26alkyl, —C1alkOC(O)C1-26alkyl, or —C1alkOC(O)OC1-26alkyl;
- or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.
3 more elements
A pharmaceutical composition comprising the compound of formula II-A
- or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.