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AssigneeNico Therapeutics, Inc.
InventorsAlex L. Bagdasarian, Robert A. Craig, II, Javier de Vicente Fidalgo, Anthony A. Estrada, Brian M. Fox, Cheng Hu, Benjamin J. Huffman, Katrina W. Lexa, Lizanne G. Nilewski, Maksim Osipov, Arun Thottumkara
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The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof. Further disclosed a method for treating a disease or condition mediated, at least in part, by NLRP3, the method comprising administering an effective amount of the pharmaceutical composition, to a subject in need thereof.
A compound or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, selected from Table 1.
A compound or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, selected from Table 2.
Dependencies are inferred from the claim text.