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US 2025/0145568 A1Published application
Deuterated organic compounds and uses thereof
AssigneeEngrail Therapeutics, Inc.
InventorsKrishna VADODARIA, Kimberly VANOVER, Vikram SUDARSAN, David GARVEY
Life of this patent
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Abstract
Provided are compounds of Formula I, described herein, processes for their preparation, their use as pharmaceuticals, and pharmaceutical compositions comprising them and intermediates used in their preparation. Compounds of Formula I are useful, for instance, in modulating dopamine neurotransmission and treating disorders that may benefit from the same, such as schizophrenia and depression.
Claims24
A compound of Formula I:
- wherein:
- R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are independently selected from H and D;
- and wherein
- at least one of R1, R2, and R3, is D;
- and at least one of R9, R10, R11, R12, and R13 is D;
- in free or salt form.
3 more elements
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A compound, wherein the compound is:
- in free or salt form.
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Dependencies are inferred from the claim text.