Stimulation of the celiac-superior mesenteric ganglion complex for treating inflammation
AssigneeThe Feinstein Institutes for Medical Research
InventorsValentin A. Pavlov, Santhoshi Poonacha Palandira, Kevin J. Tracey
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Abstract
Methods are disclosed for treating inflammatory disease states in a mammalian patient (e.g., human) by applying noninvasive focused ultrasound stimulation to the celiac-superior mesenteric ganglion complex of the patient.
Claims15
A non-invasive method to treat an inflammatory disease state in a mammalian patient comprising applying noninvasive focused ultrasound stimulation (FUS) to the patient's celiac-superior mesenteric ganglion complex (CSMGC) in an amount effective to treat the inflammatory disease state in a mammalian patient.
A method of one or both of suppressing tumor necrosis factor (TNF) levels in a mammalian patient and increasing interleukin-10 (IL-10) levels in the mammalian patient comprising applying noninvasive focused ultrasound stimulation (FUS) to the patient's celiac-superior mesenteric ganglion complex (CSMGC) in an amount effective to suppress TNF levels and/or increase IL-10 levels in a mammalian patient.
A method of enhancing an inflammatory response in a mammalian patient comprising applying noninvasive focused ultrasound stimulation (FUS) to the patient's celiac-superior mesenteric ganglion complex (CSMGC) in an amount effective to inhibit or ablate neurons and nerve endings in the CSMGC of a mammalian patient.
Dependencies are inferred from the claim text.