Microneedle integrated 3D printed micropump combined with polymeric nanoparticles for rapid release transdermal drug delivery

A transdermal drug delivery method, comprising:

• (a) having a transdermal drug delivery system comprising:
• (i) a triggering subsystem having a Shape Memory Alloy (SMA) spring attached and above an iron trigger,
• (ii) a drug delivery subsystem situated below the triggering subsystem, wherein the drug delivery subsystem has a preloaded pumping spring situated above a magnet, and as such the preloaded pumping spring is positioned in between the iron trigger and the magnet, and
• (iii) a microneedle subsystem having a pump chamber containing a drug, an elastic membrane lining an inside of the pump chamber, and an array of hollow microneedles at a bottom of the pump chamber;
• and
• (b) controlling a current to the SMA spring resulting in the SMA spring to heat and shrink to an original length of the SMA spring, thereby separating the SMA spring and attached iron trigger from the magnet resulting in extension of the preloaded pumping spring,
• wherein the extension of the preloaded pumping spring results in pushing the drug in the pump chamber through the elastic membrane and then through the array of hollow microneedles, and in case the array of hollow microneedles is in contact with a skin portion, pushing the drug via the array of hollow microneedles into the skin portion.