Medical device introducers, methods of making the same, and methods of sterilization of the same

A method of making an introducer for a medical device, the method comprising:

• forming an elongated tubing comprising a first polymer layer forming an outer surface of the introducer having an outer diameter d1 and a second polymer layer;
• forming an inner surface of the introducer and defining a lumen having a diameter d2, wherein the second layer is substantially more hydrophobic than the first layer;
• wherein the elongated tubing has a length I1,
• wherein a ratio of I1/d1 is greater than about 120 and a ratio of I1/d2 is greater than about 200 to about 2,000;
• and wherein the introducer is configured to be substantially sterilized throughout of substantially entire d1 and d2 along substantially entire I1.