3-((3-([1,1'-biphenyl]-3-ylmethoxy)phenoxy)methyl)benzonitrile derivatives and the use thereof

A compound of general formula I

• wherein
• R1 is selected from the group consisting of hydrogen, a substituted or unsubstituted C1-C6 alkyl group and bromine;
• R2 is selected from the group consisting of a substituted or unsubstituted C1-C6 alkyl group and bromine or iodine;
• R3 is selected from the group consisting of chlorine, bromine, iodine and a first leaving group AG1;
• M is hydrogen or a group R5;
• X is C—H or N, with the provision that at most two of the moieties X are N and the remaining moieties X are C—H;
• Y is selected from the group consisting of —CN, —S(O)2—CH3, fluorine, iodine and a second leaving group AG2;
• Z is selected from the group consisting of a group of general formula II, a group of general formula III, a group of general formula IV, a group of general formula V, a group of general formula VI and a group of general formula VIa
• AG1 is selected from the group consisting of an organotin group, a boronic acid and a boronic acid ester;
• AG2 is selected from the group consisting of an organotin group, a fluorosulphate group, a boronic acid and a boronic acid ester;
• R4 is a sulphonic acid group or a phosphonic acid group;
• R5 is selected from a first group or a second group, wherein
• the first group consists of a group of general formula VII or a group of general formula VIII:
• X1 is C—H or N,
• M2 is a chelate ligand or a chelate complex consisting of the chelate ligand and a central atom, wherein the central atom is selected from the group consisting of Sc-43, Sc-44, Sc-47, Cu-61, Cu-62, Cu-64, Cu-67, Ga-68, Y-86, Zr-89, Y-90, Tc-99m, In-111, La-133, Gd-153, Gd-155, Gd-157, Tb-149, Tb-152, Tb-155, Tb-161, Lu-177, Pd-197m, Pb-209, Pb-212, Bi-213, and Ac-225, m is an integer of 0 to 3, n is an integer of 1 to 7, and p is an integer of 1 to 4;
• the second group consists of a group of general formula IX, a group of general formula X, a group of general formula XI, and a group of general formula XII:
• wherein
• R6 is O-Ts or fluorine and R7 is O-Tf or fluorine, Ts designates a tosyl group and Tf designates a triflyl group.