Treatment of acquired focal epilepsy

Abstract

The invention provides methods of treatment of acquired focal epilepsy in a human subject in need of the same, the methods comprising: (i) providing an expression vector encoding a polynucleotide sequence encoding LGI1, wherein the polynucleotide sequence is operably linked to a promoter suitable to drive expression of the LGI1 in human cells, (ii) administering the expression vector to the subject. Overexpressing LGI1 has been shown to affect excitatory neurons beyond the area of expression thereby targeting a large area and affecting neurons in an advantageously uniform manner.

Dependencies are inferred from the claim text.