Nitrogen-branched non-linear pegylated lipid and application thereof

A PEGylated lipid of the general formula (1):

• wherein, X is —CRa< or
• and Ra is H or a C1-12 alkyl group;
• B1 and B2 are each independently a linking bond or a C1-20 alkylene group;
• L1 and L2 are each independently a linking bond or a divalent linking group;
• R1 and R2 are each independently a C1-50 aliphatic hydrocarbon group or a C1-50 residue of aliphatic hydrocarbon derivative, containing 0 to 10 heteroatoms;
• the heteroatom is B, O, N, Si, P or S;
• Ld is a linking bond or a divalent linking group;
• Ncore is a multivalent group having a valence of y+1, and contains a trivalent nitrogen-atom branching core connected to Ld;
• y is 2,3,4,5, 6, 7, 8 or 9, or y>10;
• y instances of Lx are each independently a linking bond or a divalent linking group;
• XPEG is a polyethylene glycol component;
• each of y instances of XPEG independently contains one, two, three or four RPEG;
• RPEG is a single-chain polyethylene glycol component containing at least 4 EO units, and the EO unit is —CH2CH2O— or —OCH2CH2—;
• RPEG in the same XPEG have the same terminal group T;
• T is a hydrogen atom, an alkyl group or R01-L01-, wherein L01 is a linking bond or a divalent linking group, and R01 is a functional group that can interact with bio-related substances;
• the alkyl group, alkylene group, aliphatic hydrocarbon group, and residue of aliphatic hydrocarbon derivative are each independently substituted or unsubstituted;
• the PEGylated lipid is monodisperse or polydisperse;
• or a salt, tautomer, stereoisomer or solvate thereof.