Programmable lipid nanoparticle delivery via corona protein engineering
AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Beth Israel Deaconess Medical Center, Inc.
InventorsOmar Abudayyeh, Jonathan Gootenberg, Cian Schmitt-Ulms, Alisan Kayabolen
Life of this patent
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Abstract
Disclosed are compositions comprising a lipid nanoparticle and a modified biomolecular corona. In some embodiments, the modified biomolecular corona comprises a fused cell-specific binding domain. In some embodiments, the modified biomolecular corona protein has been additionally modified such that it does not bind substantially to its natural receptor. In some embodiments, the fused cell-specific binding domain binds to a target cell.
Claims30
A composition, comprising a lipid nanoparticle and a modified lipid binding protein;
- wherein the modified lipid binding protein comprises a fused cell-specific binding domain;
- the modified lipid binding protein has been additionally modified such that it does not bind substantially to its natural receptor;
- and the fused cell-specific binding domain binds to a target cell.
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A composition, comprising a lipid nanoparticle and a modified lipid binding protein;
- wherein the modified lipid binding protein comprises a conjugated cell-specific binding domain;
- the modified lipid binding protein has been additionally modified such that it does not bind substantially to its natural receptor;
- and the conjugated cell-specific binding domain binds to a target cell.
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A composition, comprising a lipid nanoparticle and a modified lipid binding protein;
- wherein the lipid nanoparticle comprises a conjugated cell-specific binding domain;
- the modified lipid binding protein has been additionally modified such that it does not bind substantially to its natural receptor;
- and the conjugated cell-specific binding domain binds to a target cell.
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Dependencies are inferred from the claim text.