Nanobody-drug adducts and uses thereof
AssigneeChildren's Medical Center Corporation
InventorsHidde L. Ploegh, Xin Liu, Novalia Pishesha, Elisha Verhaar
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Abstract
Provided herein are conjugate molecules comprising an antibody or antibody fragment capable of binding polyclonal immnunoglobulins within a subject. Such conjugates are useful for recruiting immune cells of the subject to one or more cell types that are targeted by the conjugate. Also provided herein are compositions comprising the conjugates, including pharmaceutical compositions that may be administered to a subject, for such a purpose as to treat or prevent a disease.
Claims119
A conjugate comprising a first agent that binds to an immunoglobulin and a second agent that binds to a target on the surface of a cell or a pathogen, wherein the first agent and the second agent are covalently conjugated via a linker.
An antibody comprising a CDR-H1, a CDR-H2, and a CDR-H3 of any one of the antibodies listed in Table 1.
An antibody comprising a CDR-H1, a CDR-H2, and a CDR-H3 of any one of the antibodies listed in Table 2.
An antibody comprising the amino acid sequence of SEQ ID NO:
- 38.
Dependencies are inferred from the claim text.