Locally administered compositions and methods of use thereof
AssigneesFairleigh Dickinson University, Oncogone, Inc.
InventorsHyunah CHO, Xiaoban XIN
Life of this patent
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Abstract
A composition includes a first polymer, a second polymer, and one or more therapeutic agents. The first and the second polymers are PLGA-PEG-PLGA triblock copolymers. The first polymer has a molecular weight higher than the second polymer; a molar ratio of the first polymer to the second polymer is from 3:1 to 1:1; and a ratio of a weight of the one or more therapeutic agents to a total weight of the first and second polymers is at least 2%.
Claims34
A composition comprising:
- a first polymer and a second polymer;
- and
- one or more therapeutic agents,
- wherein:
- the first and the second polymers are PLGA-PEG-PLGA triblock copolymers,
- the first polymer has a molecular weight higher than the second polymer,
- a molar ratio of the first polymer to the second polymer is from 3:1 to 1:1, and
- a ratio of a total weight of the one or more therapeutic agents to a total weight of the first and second polymers is at least 2%.
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A method of producing a composition comprising:
- (a) mixing a first polymer, a second polymer, and one or more therapeutic agents in water;
- (b) mixing an organic solvent with the mixture from (a);
- and
- (c) lyophilizing the mixture from (b),
- wherein
- the first and the second polymers are PLGA-PEG-PLGA triblock copolymers,
- the first polymer has a molecular weight higher than the second polymer,
- a molar ratio of the first polymer to the second polymer is from 3:1 to 1:1, and
- a ratio of a weight of the one or more therapeutic agents to a total weight of the first and second polymers is at least 30%.
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Dependencies are inferred from the claim text.