Near-infrared photodynamic therapy using second harmonic generation nanoparticle and visible light reactive photosensitizer
AssigneeAriel Scientific Innovations Ltd.
InventorsRefael MINNES, Ayan BARBORA
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Abstract
The present invention is directed to second harmonic generation particle comprising a photosensitizer spaced by a non-ionic water-soluble spacer, method of manufacturing thereof and use thereof such as for photodynamic therapy.
Claims24
A composition comprising a plurality of nanoparticles, wherein each of said plurality of nanoparticles comprises (i) a second harmonic generation (SHG) particle, (ii) a non-ionic water-soluble spacer, and (iii) a photosensitizer;
- wherein:
- the SHG particle is configured to emit a plurality of photons at a wavelength range of between 360 and 450 nm;
- said photosensitizer is a water insoluble photosensitizer characterized by an absorbance range at least partially overlapping with said wavelength range;
- and wherein said photosensitizer is in operable communication with the SHG particle to allow excitation of said photosensitizer by said plurality of photons.
A composition comprising a plurality of nanoparticles, wherein each of said plurality of nanoparticles has a core in contact with a shell;
- wherein:
- said core comprise a SHG particle configured to emit a plurality of photons at a wavelength range of between 360 and 450 nm;
- said shell comprises a water-soluble non-ionic spacer and a photosensitizer;
- and
- said photosensitizer is a water insoluble photosensitizer characterized by an absorbance range at least partially overlapping with said wavelength range;
- said photosensitizer is spaced from said core by water-soluble non-ionic spacer to allow excitation of said photosensitizer by said plurality of photons.
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Dependencies are inferred from the claim text.