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US 2025/0144211 A1Published application
Recombinant proteins that stimulate an immune response in the presence of naturally inhibitory ligand binding
AssigneeSeattle Children's Hospital d/b/a Seattle Children's Research Institute
InventorShannon Oda
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Abstract
Recombinant proteins that stimulate an immune response in the presence of naturally inhibitory ligand binding are described. The recombinant proteins include an extracellular domain of an inhibitory immune cell protein and an intracellular domain of a stimulatory immune cell protein connected via a transmembrane domain. The recombinant proteins can be used to stimulate immune cell activation in the fight against cancers and infectious diseases, among other uses.
Claims61
A protein comprising
- an extracellular domain of Fas, CD200R, or SIRPα;
- an intracellular domain of HVEM, CD2, CD226, CRTAM, HAVCR1, SLAMF3, SLAMF5, SLAMF7, DR3, CD30, or LIGHT;
- and
- a transmembrane domain linking the extracellular domain to the intracellular domain.
1 more element
A protein comprising
- an extracellular domain of Fas, CD200R, or SIRPα;
- an intracellular domain of CD40, ICOS, SLAMF1, CD27, GITR, or OX40;
- and
- a transmembrane domain linking the extracellular domain to the intracellular domain.
1 more element
Dependencies are inferred from the claim text.