Nanostructure-based vector system for bacterial and viral antigens

A nanostructured vector system comprising a complex of Lipid A-SAEP (Synthetic Anti Endotoxin Peptide) or a Lipid A derivative-SAEP derivative incorporating at least one helper T-cell dependent carrier antigen, selected from the group consisting of CRM197, Diphtheria Toxoid, Tetanus Toxoid, Pertussis Toxoid or a combination thereof;

• wherein said Lipid A derivative is an R-LPS or an R/S-LPS or an S-LPS chemotype and wherein said SAEP derivative is a cationic and amphipathic peptide structure in a linear or cyclic conformation with a ratio between cationic and hydrophobic amino acids of ≥0.5, wherein the helper T-cell dependent carrier antigen is not incorporated in the nanostructured vector system via covalent bonds.

A conjugated hybrid antigen comprising a) the bacterial protein CRM197 and b) a viral SARS CoV-2 S-protein expressed by anyone of the SARS CoV-2 S Variants of Concern, said hybrid antigen being in trimeric conformation.