Active agent depots formed in situ for maintaining long-term lesion patency

Abstract

Embodiments herein relate to forming active agent releasing depots in situ for maintaining patency of lesions over extended terms. A method herein of forming an active agent releasing depot in situ for maintaining patency of lesions over extended terms can include contacting a composition with a vessel wall. The composition includes an active agent and a fibrin promoting vessel wall transfer agent, wherein the ratio of active agent to fibrin promoting vessel wall transfer agent (wt./wt.) is at least 5:1. The method can include transferring the composition from a device surface to the vessel wall surface and forming an initial fibrin matrix around the composition. The transferred composition can be effective to maintain patency of targeted lesions over a period at least 6 months. Other embodiments are also included herein.

Dependencies are inferred from the claim text.