Composition and methods for regulating chondrocyte proliferation and increasing of cartilage matrix production
Assignees4Moving Biotech, Sorbonne Universite
InventorsFrancis BERENBAUM, Revital RATTENBACH
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Abstract
A pharmaceutical compositions includes GLP-1 and GLP-1 analogues inducing an anabolic stimulation of chondrocytes and a decreasing in chondrocyte catabolic including a decrease in cartilage matrix loss and cartilage degeneration for use in the treatment of cartilage disease. The composition induces cartilage regeneration and anabolic stimulation of chondrocytes, including chondrocyte proliferation and/or stem cell differentiation into chondrocytes.
Claims8
A method for improving synovial membrane health in an osteoarthritis patient, comprising administering to said patient Glucagon Like Peptide-1 (GLP-1) or a GLP-1 analogue, or a composition comprising said GLP-1 or GLP-1 analogue.
Dependencies are inferred from the claim text.