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US 2025/0144157 A1Published application
Glycan strands and oligosaccharides derived from streptococcus bacteria
AssigneeMeharry Medical College
InventorsBindong Liu, Qiujia Shao
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Abstract
Compositions of glycan strands and oligosaccharides derived from gram-positive bacteria and methods of use thereof are provided. The disclosed compositions have inhibitory activity toward both early and late stages of viral infection and transmission. The disclosed compositions may be used to treat and/or prevent infection and transmission of viruses, such as HIV, to upregulate one or both of AG3 and MX2, to enhance immune function, and/or to inhibit replication of a virus.
Claims20
A method of making a glycan strand extract from a Streptococcus cell, comprising:
- isolating a cell wall component from the Streptococcus cell to form an isolated cell wall composition;
- cleaving the bonds between a glycan and at least one of teichoic acid or peptides in the isolated cell wall composition to form a first digest;
- and
- reducing the concentration of the at least one of teichoic acid or peptides in the first digest to form the glycan strand extract.
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Dependencies are inferred from the claim text.