Methods of protecting implanted or transplanted cells and tissues from immune rejection
AssigneesMUSC Foundation for Research Development, Clemson University
InventorsLeonardo M.R. FERREIRA, Ying MEI, Dimitrios Chrisovalantou ARHONTOULIS, Jaime VALENTIN-QUIROGA
Life of this patent
Estimating the term…
Abstract
The present disclosure is directed to method for the generation and use of regulatory T cells (Tregs) in the prevention and treatment of graft/transplant rejection. In particular, the method employs engineered CAR Treg cells that protect transplanted materials from rejection.
Claims22
A method of protecting an implanted cell, tissue, organ or organoid from immune response in a recipient subject comprising administering to said recipient subject a chimeric antigen receptor (CAR) T regulatory cell (Treg), wherein said CAR Treg recognizes a natural or artificial antigen that (a) is not found in said implanted cell, tissue, organ or organoid and is (b) co-administered with said implanted cell, tissue, organ or organoid or found in proximity to said implanted cell, tissue, organ or organoid once implanted.
A method of transplanting a cell, tissue, organ, or organoid into a subject comprising:
- (a) transplanting a cell, tissue, organ, or organoid into a subject;
- and
- (b) introducing into the subject a chimeric antigen receptor (CAR) T regulatory cell (Treg), wherein said CAR Treg recognizes a natural or artificial antigen that (a) is not found in said implanted cell, tissue, organ or organoid and is (b) found in proximity to said implanted cell, tissue, organ or organoid once implanted.
A method of transplanting a cell, tissue, organ, or organoid into a subject comprising:
- (a) transplanting a cell, tissue, organ or organoid into a subject;
- and
- (b) administering to the subject (i) a chimeric antigen receptor (CAR) T regulatory cell (Treg), wherein said CAR Treg recognizes a natural or artificial antigen that is not found in said implanted cell, tissue, organ or organoid;
- and (ii) said natural or artificial antigen,
- wherein said natural or artificial antigen co-administered with said CAR Treg or implanted at or near the site at which said cell, tissue, organ, or organoid is implanted.
A kit comprising (a) a chimeric antigen receptor (CAR) T regulatory cell (Treg) and (b) a natural or artificial antigen recognized by said CAR Treg, optionally wherein said antigen is associated with a particle (microparticle or nanoparticle), a polymer, a cell, a synthetic cell, or a synthetic cell surrogate.
Dependencies are inferred from the claim text.