Chimeric Antigen Receptor Therapies and Vasoactive Intestinal Peptide Receptor Antagonists
AssigneeEmory University
InventorsSarwish Rafiq, Sruthi Ravindranathan, Edmund K. Waller, Heather Kelsey Lin
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Abstract
This disclosure relates to compositions and methods of treating disorders such as cancer using immune effector cells (e.g., T cells or NK cells) that express a chimeric antigen receptor (CAR). In certain embodiment, this disclosure relates to methods of using a CAR-expressing cell therapy in combination with a vasoactive intestinal peptide receptor antagonist.
Claims20
A composition comprising
- a first nucleic acid sequence encoding a chimeric antigen receptor (CAR) molecule that binds to an antigen and
- a second nucleic acid sequence encoding a vasoactive intestinal peptide receptor antagonist.
A recombinant vector comprising a nucleic acid encoding a vasoactive intestinal peptide receptor antagonist having of the amino acid of Y X1 X2 N X3 T X4 L R K Q X5 A V X6 K Y X7 N X8 I L N (SEQ ID NO:
- 11), wherein X1 is A or any amino acid:
- X2 is V or any amino acid;
- X3 is C or any amino acid;
- X4 is S or any amino acid:
- X5 is I or any amino acid;
- X6 is N or any amino acid:
- X7 is M or any amino acid:
- X8 is I or any amino acid in operable combination with a heterologous promotor.
An immune cell comprising a nucleic acid or recombinant vector comprising a nucleic acid encoding a vasoactive intestinal peptide receptor antagonist having of the amino acid of Y X1 X2 N X3 T X4 L R K Q X5 A V X6 K Y X7 N X8 I L N (SEQ ID NO:
- 11), wherein X1 is A or any amino acid;
- X2 is V or any amino acid;
- X3 is C or any amino acid:
- X4 is S or any amino acid:
- X5 is I or any amino acid:
- X6 is N or any amino acid:
- X7 is M or any amino acid:
- X8 is I or any amino acid.
A method of treating cancer or other immune cell disease or condition comprising,
- contacting, inserting, or transfecting the immune cells with a nucleic acid or recombinant vector encoding a chimeric antigen receptor and encoding vasoactive intestinal peptide receptor antagonist having of the amino acid of Y X1 X2 N X3 T X4 L R K Q X5 A V X6 K Y X7 N X8 I L N (SEQ ID NO:
- 11), wherein X1 is A or any amino acid;
- X2 is V or any amino acid:
- X3 is C or any amino acid:
- X4 is S or any amino acid:
- X5 is I or any amino acid:
- X6 is N or any amino acid:
- X7 is M or any amino acid:
- X8 is I or any amino acid, as providing immune cells expressing the chimeric antigen receptor and vasoactive intestinal peptide receptor antagonist;
- and
- administering an effective amount of chimeric antigen receptor and vasoactive intestinal peptide receptor antagonist expressing immune cells to a subject in need thereof.
Dependencies are inferred from the claim text.