Amide compound as potassium channel regulator, and preparation therefor and use thereof

A compound of formula I, or a pharmaceutically acceptable salt thereof,

• wherein,
• ring A is selected from the group consisting of:
• none, C6-10 aryl, 4-7-membered heteroaryl containing 1-3 heteroatoms selected from N, O and S, saturated or unsaturated C3-6 cyclic hydrocarbon group, and 3-10-membered heterocyclyl containing 1-3 heteroatoms selected from N, O and S;
• R1, R2, R3 and R4 are independently selected from the substituted or unsubstituted group consisting of:
• hydrogen, deuterium, halogen, cyano, —OH, —COOH, nitro, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C3-6 cycloalkyloxy, C2-6 alkenyl, C2-6 alkynyl, saturated or unsaturated C3-6 cyclic hydrocarbon group, 3-10-membered heterocyclyl containing 1-3 heteroatoms selected from N, O and S, C6-10 aryl, 5-14-membered heteroaryl containing 1-3 heteroatoms selected from N, O and S, C6-12 arylalkyl, —N(R1′)(R2′), —C(O)—R1′, —C(O)—N(R1′)(R2′), —C(O)—OR1′, —N (R1′)—C(O)—R2′, —S(O)m—R1′, —S(O)m—N(R1′)(R2′), —S(O)m—OR1′, and —N(R1′)—S(O)m—R2′, and the “substituted” refers to being substituted by one or more substituents selected from the group consisting of:
• halogen, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C3-6 cycloalkyloxy, C1-6 haloalkyl, C3-6 halocycloalkyl, C1-6 haloalkoxy and C3-6 halocycloalkyloxy;
• n and r are independently selected from the group consisting of:
• 0, 1 and 2;
• R1′ and R2′ are independently selected from the group consisting of:
• hydrogen, C1-6 alkyl, C3-6 cycloalkyl, or R1′ and R2′ together with the attached N-atom form a saturated or unsaturated 3-10-membered heterocyclyl containing 1-3 heteroatoms selected from N, O and S;
• and the above alkyl, cycloalkyl and heterocyclyl are optionally substituted by one or more substituents selected from the group consisting of:
• ═O, halogen, C1-6 alkyl and C3-6 cycloalkyl;
• m is selected from the group consisting of:
• 1 and 2;
• W1 and W2 are independently selected from the group consisting of:
• none, C and N;
• and
• W1 and W2 are not simultaneously none;
• is selected from the group consisting of:
• none, single bond and double bond;
• ring B is selected from the group consisting of:
• C6-10 aryl, 4-7-membered heteroaryl containing 1-3 heteroatoms selected from N, O and S, saturated or unsaturated C3-10 cyclic hydrocarbon group, 3-10-membered heterocyclyl containing 1-3 heteroatoms selected from N, O and S, 3-10-membered bridged heterocyclyl containing 1-3 heteroatoms selected from N, O and S;
• V is selected from the group consisting of:
• C, CR8 and N;
• R8 is selected from the group consisting of:
• hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl and C2-6 alkynyl;
• and the above alkyl and cycloalkyl are optionally substituted by one or more substituents selected from the group consisting of halogen, C1-6 alkyl and C3-6 cycloalkyl;
• V′ is selected from the group consisting of:
• —(CH2)p—, —C(CH3)2—,
• —NH—, —(CH2)p—NH—, —CF2—NH—, —C(CH3)2—NH— and
• p is selected from the group consisting of:
• 0, 1 and 2;
• X and Y are independently selected from the group consisting of:
• N and CR 9;
• R9 is selected from the group consisting of:
• hydrogen, halogen, cyano, amino, hydroxyl, C1-6 alkyl, C3-6 cycloalkyl and C1-6 alkoxy;
• and the above amino, alkyl, cycloalkyl and alkoxy are optionally substituted by one or more substituents selected from the group consisting of halogen, C1-6 alkyl, and C3-6 cycloalkyl;
• R5 and R6 are independently selected from the group consisting of:
• hydrogen, halogen, cyano, amino, hydroxyl, C1-6 alkyl, C3-6 cycloalkyl and C1-6 alkoxy;
• and the above amino, alkyl, cycloalkyl and alkoxy are optionally substituted by one or more substituents selected from the group consisting of halogen, C1-6 alkyl and C3-6 cycloalkyl;
• U is selected from the group consisting of:
• O, S and N(R10);
• Z is selected from the group consisting of:
• O, —(CH2)q—and —N(R11)—;
• q is selected from the group consisting of:
• 0, 1 and 2;
• R10 and R11 are independently selected from the group consisting of:
• hydrogen, C1-6 alkyl and C3-6 cycloalkyl;
• and the above alkyl and cycloalkyl are optionally substituted by one or more substituents selected from the group consisting of halogen, C1-6 alkyl and C3-6 cycloalkyl;
• R7 is selected from the group consisting of:
• C1-6 alkyl, C3-6 cycloalkyl, C5-8 bridged cyclic group, adamantyl, C6-10 aryl, 3-10-membered heteroaryl containing 1-3 heteroatoms selected from N, O and S, 4-8-membered heterocycloalkyl containing 1-3 heteroatoms selected from N, O and S, C3-6 cycloalkenyl, C2-6 alkenyl and C2-6 alkynyl;
• and the above alkyl, cycloalkyl, bridged cyclic group, adamantyl, aryl, heteroaryl, heterocycloalkyl, cycloalkenyl, alkenyl, and alkynyl are optionally substituted by one or more substituents selected from the group consisting of:
• hydrogen, halogen, cyano, nitro, amino, hydroxyl, C1-6 alkyl-CO-, C1-6 alkyl, C3-6 cycloalkyl, C6-10 aryl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino and C1-6 haloalkoxy.