Compositions of autophagy modulating agents and uses thereof
AssigneeWashington University
InventorsDavid Perlmutter, Roland Dolle, Stephen Pak, Gary Silverman
Life of this patent
Estimating the term…
Abstract
Among the various aspects of the present disclosure is the provision of compositions and methods for modulating autophagy for treatment and prevention of autophagy-associated diseases, disorders, or conditions and compositions of photoreactive compounds. An aspect of the present disclosure provides for autophagy enhancing agents capable of treating or preventing diseases, disorders, or conditions in which autophagy is implicated.
Claims31
A composition comprising an autophagy modulating agent selected from formula (I):
- wherein R1, R2, R3, R4, R5, or R6 is hydrogen (H), halo (e.g., Cl, F), C1-8alkyl (e.g., methyl, ethyl, butyl, propyl, isopropyl, isopentyl), halogen-substituted C1-8alkyl (e.g., trifluoromethyl), piperidinyl (e.g., piperidin-1, 2, 3, or 4-yl), C3-10cycloalkyl (e.g., phenyl), halogen-substituted C3-10cycloalkyl (e.g., chlorophenyl), pyrimidinyl (e.g., pyrimidin-2,4, or 5, -yl), C1-8alkoxy (e.g., methoxy, ethoxy, propoxy, butoxy, hexoxy), halogen substituted C1-8alkyl (e.g., trifluoromethyl, trifluorobutoxy, trifluoropentoxy), C1-6alkyl-C3-10cycloalkoxy (e.g., cyclopropylethoxy), C3-10cycloalkyl-C1-6alkyl-amino (e.g., cyclopropylethylamino, cyclopropylethyl(methyl)amino), C3-10heterocyclyloxy (e.g., piperidinyloxy, cyclopentylpiperidinyloxy), C1-8alkylsulphonyl (e.g., methyl sulfonyl), C1-8alkylsulphonylalkoxy (e.g., methyl sulfonylpropoxy), C1-10cycloalkoxy (e.g., phenyl propoxy), alkoxyC1-10cycloalkyl (e.g., methoxy phenyl), substituted phenyl;
- and/or
- R1 or R2, R2 or R3, or R3 or R4 optionally form a ring (e.g., heterocyclyl, cycloalkyl, furanyl, pyridinyl, phenyl, etc.);
- a 5 or 6 membered ring (e.g., pyridinyl, furanyl, cycloalkyl, heterocyclyl);
- a substituted 5- or 6-membered ring (e.g., an alkyl-, alkyl-phenyl-, hydroxyl-, halo-, chloro-, bromo-, methoxy-, di-methoxy-, oxy-, or benzyl-substituted 5 or 6 membered ring);
- or a substituted bicyclic group (e.g., indole, azobicyclo, bridged bicyclic).
A method of modulating autophagy or treating or preventing an autophagy-associated disease, disorder, or condition in a subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising an autophagy modulating agent selected from formula (I):
- wherein R1, R2, R3, R4, R5, or R6 is hydrogen (H), halo (e.g., Cl, F), C1-8alkyl (e.g., methyl, ethyl, butyl, propyl, isopropyl, isopentyl), halogen-substituted C1-8alkyl (e.g., trifluoromethyl), piperidinyl (e.g., piperidin-1, 2, 3, or 4-yl), C3-10cycloalkyl (e.g., phenyl), halogen-substituted C3-10cycloalkyl (e.g., chlorophenyl), pyrimidinyl (e.g., pyrimidin-2,4, or 5, -yl), C1-8alkoxy (e.g., methoxy, ethoxy, propoxy, butoxy, hexoxy), halogen substituted C1-8alkyl (e.g., trifluoromethyl, trifluorobutoxy, trifluoropentoxy), C1-6alkyl-C3-10cycloalkoxy (e.g., cyclopropylethoxy), C3-10cycloalkyl-C1-6alkyl-amino (e.g., cyclopropylethylamino, cyclopropylethyl(methyl)amino), C3-10heterocyclyloxy (e.g., piperidinyloxy, cyclopentylpiperidinyloxy), C1-8alkylsulphonyl (e.g., methyl sulfonyl), C1-8alkylsulphonylalkoxy (e.g., methyl sulfonylpropoxy), C1-10cycloalkoxy (e.g., phenyl propoxy), alkoxyC1-10cycloalkyl (e.g., methoxy phenyl), substituted phenyl;
- and/or
- R1 or R2, R2 or R3, or R3 or R4 optionally form a ring (e.g., heterocyclyl, cycloalkyl, furanyl, pyridinyl, phenyl, etc.);
- a 5 or 6 membered ring (e.g., pyridinyl, furanyl, cycloalkyl, heterocyclyl);
- a substituted 5- or 6-membered ring (e.g., an alkyl-, alkyl-phenyl-, hydroxyl-, halo-, chloro-, bromo-, methoxy-, di-methoxy-, oxy-, or benzyl-substituted 5 or 6 membered ring);
- or a substituted bicyclic group (e.g., indole, azobicyclo, bridged bicyclic).
Dependencies are inferred from the claim text.