1 h-pyrazolo[4,3-d]pyrimidine derivatives as staphylococcus aureus inhibitors

A method of preventing or treating a condition or a disease or a disorder caused by Staphylococcus aureus (S. aureus) in a subject, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I):

• or a pharmaceutically acceptable salt, a pharmaceutically acceptable stereoisomer, a pharmaceutically acceptable hydrate, a pharmaceutically acceptable solvate, a prodrug, a polymorph, an N-oxide or a bioisostere thereof, wherein:
• each R is independently selected from hydrogen, halogen, hydroxyl, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl, and optionally substituted heteroaryl;
• Ar is an aryl or heteroaryl;
• and
• Het represents an optionally substituted heterocyclyl or heteroaryl connected through a C—C bond.