Pharmaceutical compositions of roflumilast and solvents capable of dissolving high amounts of the drug
AssigneeArcutis Biotherapeutics, Inc.
InventorsDavid W. OSBORNE, Babak N. TOFIG, Frank WATANABE
Life of this patent
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Abstract
Topical pharmaceutical compositions comprising roflumilast and solvents that are capable of dissolving high amounts of roflumilast. The pharmaceutical compositions are capable of dissolving high amounts of roflumilast relative to other commonly used solvents in approved topical pharmaceutical compositions. The solvents are particularly useful when combined with water to maintain high levels of dissolved roflumilast, which is highly insoluble in water.
Claims20
A method of treating a patient suffering from an inflammatory or allergic dermatosis, the method comprising topically applying to the patient a pharmaceutical composition comprising a pharmaceutically effective amount of roflumilast, water, and a pharmaceutically acceptable solvent selected from the group consisting of 1,3-butylene glycol, 1,2-hexanediol, 1,3-propanediol, 1,2-pentanediol, dipropylene glycol, 2-(2-butoxy-ethoxy)ethanol, 1,6-hexanediol, propylene glycol methyl ethyl acetate, 5-methyloxolan-2-one, pantolactone, and combinations thereof.
Dependencies are inferred from the claim text.