Compositions and methods for treating biofilms
AssigneeThe Regents of the University of California
InventorsClarissa J. Nobile, Megha Gulati
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Abstract
The disclosure provides compositions comprising amino acids, individually and in combination, and methods of making the compositions and methods of using the compositions as pharmaceutically active agents to, inter alia, treat disease in animals, including humans.
Claims19
A method of inhibiting or disrupting a biofilm on a surface, treating a bacterial infection in a subject in need thereof, or treating a fungal infection in a subject in need thereof, the method comprising contacting the surface with a composition or administering a composition to the subject;
- wherein the composition comprises:
- (a) a first compound of formula (I) or a salt thereof, wherein
- (i) R1 is —SR5, and
- (ii) R5 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-12 carbocycle, or 3 to 12 membered heterocycle;
- optionally substituted with one or more substituents selected from the group consisting of halogen, —CN, —NO2, —OH, —NH2, —COOH, and —OCH3, and
- (iii) n is 0, 1, 2, 3, 4, or 5;
- (b) a second compound of formula (I) or a salt thereof, wherein
- (i) R1 is —CO(O)R5, and
- (ii) R5 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-12 carbocycle, or 3 to 12 membered heterocycle;
- optionally substituted with one or more substituents selected from the group consisting of halogen, —CN, —NO2, —OH, —NH2, —COOH, and —OCH3, and
- (iii) n is 0, 2, 3, 4, or 5;
- (c) a third compound of formula (I) or a salt thereof, wherein
- (i) R1 is —CO(O)R5, and
- (ii) R5 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-12 carbocycle, or 3 to 12 membered heterocycle;
- optionally substituted with one or more substituents selected from the group consisting of halogen, —CN, —NO2, —OH, —NH2, —COOH, and —OCH3, and
- (iii) n is 0, 1, 3, 4, or 5;
- wherein the compound of formula (I) is:
- wherein:
- R2 and R3 are hydrogen;
- or one of R2 and R3 is hydrogen, and the other of R2 and R3 with R1 is taken together with the atoms to which they are attached to form a heterocycle substituted with one or more R6;
- each R6 is independently halogen, —NO2, —CN, —OR5, —SR5, —N(R5)2, —C(O)R5, —C(O)OR5,
- —OC(O)R5, —OC(O)OR5, —OC(O)N(R5)2, —NR5C(O)R5, —C(O)N(R5)2, ═O, ═S, ═N(R5), C1-10 alkyl, C2-10 alkenyl, or C2-10 alkynyl;
- each of which is independently and optionally substituted at each occurrence with one or more substituents selected from the group consisting of halogen, —CN,
- —NO2, —OH, —NH2, —COOH, and —OCH3.
A method of inhibiting or disrupting a biofilm on a surface, treating a bacterial infection in a subject in need thereof, or treating a fungal infection in a subject in need thereof, the method comprising contacting the surface with a composition or administering a composition to the subject;
- wherein the composition comprises:
- (a) a first compound of formula (I) or a salt thereof, wherein
- (i) R1 is —SR5, and
- (ii) R5 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-12 carbocycle, or 3 to 12 membered heterocycle;
- optionally substituted with one or more substituents selected from the group consisting of halogen, —CN, —NO2, —OH, —NH2, —COOH, and —OCH3, and
- (iii) n is 0, 1, 2, 3, 4, or 5;
- (b) a second compound of formula (I) or a salt thereof, wherein
- (i) R1 is —CO(O)R5, and
- (ii) R5 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-12 carbocycle, or 3 to 12 membered heterocycle;
- optionally substituted with one or more substituents selected from the group consisting of halogen, —CN, —NO2, —OH, —NH2, —COOH, and —OCH3, and
- (iii) n is 0, 2, 3, 4, or 5;
- (c) a third compound of formula (I) or a salt thereof, wherein
- (i) R1 is —CO(O)R5, and
- (ii) R5 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-12 carbocycle, or 3 to 12 membered heterocycle;
- optionally substituted with one or more substituents selected from the group consisting of halogen, —CN, —NO2, —OH, —NH2, —COOH, and —OCH3, and
- (iii) n is 0, 1, 3, 4, or 5;
- wherein the compound of formula (I) is:
- wherein:
- R2 and R3 are hydrogen;
- or one of R2 and R3 is hydrogen, and the other of R2 and R3 with R1 is taken together with the atoms to which they are attached to form a heterocycle substituted with one or more R6;
- and
- each R6 is independently halogen, —NO2, —CN, —OR5, —SR5, —N(R5)2, —C(O)R5, —C(O)OR5,
- —OC(O)R5, —OC(O)OR5, —OC(O)N(R5)2, —NR5C(O)R5, —C(O)N(R5)2, ═O, ═S, ═N(R5), C1-10 alkyl, C2-10 alkenyl, or C2-10 alkynyl;
- each of which is independently and optionally substituted at each occurrence with one or more substituents selected from the group consisting of halogen, —CN,
- —NO2, —OH, —NH2, —COOH, and —OCH3.
Dependencies are inferred from the claim text.